In Diablo 4, Runewords are powerful combinations of specific runes that can be embedded into weapons, armor, and other gear, granting significant buffs and unique effects. These Runewords can drastically enhance your gameplay, giving you an edge in combat and helping you adapt your character to a wide variety of situations. Among the Diablo IV Items most intriguing elements in Diablo 4's endgame content is the Vessel of Hatred system, which opens up new possibilities for crafting and customizing gear.

This guide dives deep into the Vessel of Hatred, covering all the available Runewords, their effects, and how to obtain them. Whether you are aiming to maximize your character's potential in PvE, PvP, or endgame content, understanding these Runewords and their locations is crucial for success.

1. What is the Vessel of Hatred?
The Vessel of Hatred is an advanced crafting system introduced in Diablo 4, unlocking powerful Runewords that can drastically alter your character's abilities. To use the Vessel of Hatred system, players must first progress through the endgame content, typically after reaching the endgame zones and unlocking access to this particular crafting feature.

In simple terms, the Vessel of Hatred allows players to socket runes into specific gear, crafting unique Runewords that provide strong buffs or new abilities. This system is essential for maximizing your character’s power in later stages of the game and experimenting with different combinations to suit your playstyle.

The Vessel of Hatred system works like a "crafting altar", where players can imbue their equipment with special runes to create Runewords. This system adds a strategic layer to gear progression, giving players more control over their build and ability loadout.

2. How to Unlock the Vessel of Hatred
Before you can start crafting Runewords in the Vessel of Hatred, you need to unlock the system. This is typically achieved by progressing through Diablo 4's main story and endgame content. Here's a step-by-step guide to unlocking the Vessel of Hatred:

Complete the Main Campaign: Finish the main story of Diablo 4 to unlock access to the full set of features and endgame zones. Once you reach a certain level and defeat key bosses, the Vessel of Hatred system will become available.

Reach the Endgame Zones: Once you've finished the story, you'll need to explore specific endgame zones where the Vessel of Hatred can be found. These zones often feature higher-level content, making them the perfect place for powerful Runewords.

Visit the Crafting Altar: After reaching the necessary level and zone, head to the Crafting Altar, where you can start crafting your Runewords. You will need Vessel Fragments, which are obtained from special quests and challenges in these zones.

Collect Runestones: Runestones are essential to crafting Runewords. You can find them by defeating bosses or completing special events in the game. They serve as the building blocks for each Runeword, with specific combinations needed for each one.

3. How to Craft Runewords
Once you have unlocked the Vessel of Hatred, it’s time to begin crafting. Here's a quick overview of the process:

Find the Correct Runes: Each Runeword requires specific runes, which can be found through quests, dungeon completions, and defeating certain monsters or bosses. Runestones come in various forms, such as Fire Runes, Ice Runes, and Death Runes, and each Runeword will require a specific combination of these.

Place Runes into the Altar: At the Crafting Altar, you will be able to combine different runes in specific patterns. The more complex the combination, the more powerful the Runeword will be. Some Runewords require two runes, while others may require up to five runes.

Imbue Your Gear: Once you've crafted a Runeword, you can embed it into your gear. Typically, you can socket your Runeword into specific weapons, armor, or accessories. The item must be compatible with the Runeword for it to work. If you’ve created the right combination of runes, you’ll be able to see the benefits immediately on your character.

Experiment and Reforge: One of the great aspects of the Vessel of Hatred system is that it encourages experimentation. Feel free to try different rune combinations and see what works best for your playstyle. If you don’t like the effects of a particular Runeword, you can reforge your gear and try again.

4. List of All Runewords and Their Effects
There are a variety of Runewords in Diablo 4, each offering distinct effects that can complement different playstyles. Here's a breakdown of all the known Runewords, along with their effects and where to find the runes required to craft them.

1. Inferno's Wrath
Runes Required: Fire Rune, Destruction Rune

Effect: Increases fire damage and creates a flame explosion when an enemy is defeated.

Where to Find Runes:

Fire Rune: Drops from Hellfire Chests in endgame zones.

Destruction Rune: Obtained by defeating the Infernal Overlord boss in the Inferno Zone.

2. Glacial Storm
Runes Required: Ice Rune, Frost Rune, Control Rune

Effect: Summons a freezing storm that reduces enemy movement speed and freezes enemies within the area of effect.

Where to Find Runes:

Ice Rune: Found by completing the Frozen Caverns Dungeon.

Frost Rune: Drops from Elite Ice Mages in the Frozen Peaks.

Control Rune: Acquired by completing special quests in the Frozen Temple.

3. Echo of Death
Runes Required: Death Rune, Shadow Rune, Soul Rune

Effect: Grants a chance to apply Death's Embrace, which causes enemies to take bonus damage after they are hit.

Where to Find Runes:

Death Rune: Drops from Necromancer Champions in The Void.

Shadow Rune: Can be obtained from Shadow Lord’s minions in The Dark Hollow.

Soul Rune: Acquired by completing high-level bounty quests in The Forsaken Vale.

4. Divine Light
Runes Required: Light Rune, Guardian Rune

Effect: Summons an aura of light that heals allies in the cheap Diablo 4 materials radius and grants bonus defense against dark magic.

Where to Find Runes:

Light Rune: Drops from Angelic Guardians in Heaven's Reach.

Guardian Rune: Acquired by completing Guardian Trials in The Citadel of Light.