Numerous men have been using 20mg Pfizer Viagra tablets in Pakistan to treat erectile dysfunction, and it has been seen that the drug affects a man's cardiovascular system in addition to his sexual performance. In males using Viagra, the heart was shown to be less affected by hormone stress. When tested on mice, the research stood out because of its potential to counteract the long-term damage caused by persistent hypertension.

The research was conducted to see whether Viagra's impact of widening vaginal blood vessels to sustain an erection has any effect on the human heart. It was also shown to have therapeutic promise in the management of pulmonary hypertension. The experts from Johns Hopkins University led this investigation. Before that discovery, however, Viagra had never been attributed to any cardiovascular side effects.

Viagra may help reduce your heart rate, which has been elevated due to chemical stress. It helps lessen the effort required for the heart to transport an excessive volume of blood throughout the body.

After testing Viagra's efficacy in preventing the short-term effects of hormonal stressors on the heart in mice, researchers led by cardiologist and Johns Hopkins study senior author David Kass, M.D., made this discovery. Viagra may also counteract the long-term effects of hypertension on the heart. Although David Kass, M.D., and colleagues found that Viagra mitigated the damaging effects of heart failure and ventricular hypertrophy on weakening heart muscles in animal tests, no convincing data has been accumulated to support this finding in humans.

The Johns Hopkins research confirmed this by showing that Viagra may reduce the heart rate response to dobutamine. Thirty-five men and women participated in a six-month study at Johns Hopkins. Before and after dobutamine injection (dobutamine is a synthetic derivative of dopamine that raises heart rate and cardiac contraction), necessary tests of heart function were done, including echocardiography, ECG, and blood pressure readings. The results revealed a 150% rise in heart rate and cardiac contractions. The participants were then randomly assigned to either receive sildenafil (Viagra) or a sugar tablet placebo. To further examine the effects of sildenafil and the sugar placebo on the heart, the participants were administered dobutamine once more. The results revealed that the heart rates and cardiac contractions of the first group dropped by nearly half, while those of the second group jumped by around 150%.

The positive results of the Johns Hopkins trial prompted more studies of sildenafil's mechanism of action, with a focus on its short- and long-term effects on the heart and other possible advantages.