The global Active Pharmaceutical Ingredients and High Potency API Industry was estimated at USD 233.31 billion in 2021 and is anticipated to increase at a significant CAGR of 6.0% from 2022 to 2030.

Grand View Research’s API and High Potency API industry databook is a collection of market sizing & forecasts insights, regulatory & technology framework, pricing intelligence, competitive benchmarking analyses, macro-environmental analyses studies. Within the purview of the database, such information is systematically analyzed and provided in the form of summary presentations and detailed outlook reports on individual areas of research.

Active Pharmaceutical Ingredients Market Insights

The global active pharmaceutical ingredients market size was estimated at USD 209.71 billion in 2021 and is expected to grow at a compound annual growth rate (CAGR) of 5.9% from 2022 to 2030. Advancements in Active Pharmaceutical Ingredient (API) manufacturing, growth of the biopharmaceutical sector, and an increase in geriatric population are among the key drivers of API market. An increase in prevalence of chronic diseases, such as cardiovascular diseases and cancer, is anticipated to boost market growth.

Increasing prevalence of infectious diseases and hospital-acquired infections is driving market growth. In addition, growing incidence of cardiovascular, genetic, and neurologic disorders is anticipated to act as a high-impact-rendering driver for market growth. Cardiovascular Diseases (CVDs) are the most prevalent causes of death globally. According to WHO, cardiovascular diseases cause death of 17.9 million people per day and are expected to cause approximately 25 million deaths by 2030. Increasing epidemiology of lifestyle, aided with rising number of smokers globally, growing incidence of obesity, and increasing dietary irregularities, are factors likely responsible to propel market growth. A recent report by the United Nations (UN) in May 2023 suggests that there has been a 75% increase in the number of girls and 61% in the number of boys with obesity in Europe.

Outsourcing of APIs has become profitable over in-house production. However, this trend took a different turn during the COVID-19 pandemic. Companies are looking to diversify their API suppliers and manufacturers to different locations instead of outsourcing it to just one manufacturer. In addition, risk mitigation is done using dual sourcing to ensure a continuous supply. Hence, key companies aim to capitalize on this ongoing outsourcing trend with new acquisitions. For instance, in August 2023, EUROAPI announced its deal to acquire BianoGMP to enhance its CDMO expertise in oligonucleotide manufacturing, which is a high-growth industry. This further demonstrates the company’s plans for vertical integration.

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High Potency API Market Insights

The global high potency active pharmaceutical ingredients market size was estimated at USD 23.60 billion in 2021 and is expected to expand at a compound annual growth rate (CAGR) of 6.2% from 2022 to 2030. High potency active pharmaceutical ingredients (HPAPI) market is witnessing growth due to the factors such as thegrowing applications of HPAPI, increasing prevalence of cancer, and growth of targeted therapies.Rise in the incidence of cancer has resulted in increase in R&D pertaining to anticancer drugs, which is expected to boost the growth of the HPAPI market over the forecast period.

The HPAPI market is experiencing a surge in demand for products with the rise in the adoption of cancer therapeutics. Cancer is considered one of the prominent health hazards due to the increasing number of people being affected by the disease. According to WHO, cancer accounted for 10 million deaths in 2020which equals nearly one in six deaths, making it the leading cause of death worldwide. The research initiatives and the presence of health awareness campaigns are expected to fuel the global HPAPI market growth.

Moreover, market players are focusing on developing novel drugs to meet the growing demand for the production of active ingredients. For instance, in July 2022,  for its site in Mourenx, the Novasep-PharmaZell Group invested USD 7.3 million as part of a bigger initiative backed by the "France Relance Plan” to increase API and HPAI production capacity. The production of active pharmaceutical ingredients (APIs), notably the extremely potent medicines (HPAPIs) used to treat cancer, will continue to be in high demand, which will support the expansion of the Mourenx site.

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Active Pharmaceutical Ingredients and High Potency API Industry Data Book Competitive Landscape

Competitive rivalry in this market is likely to be high due to increasing interest in small molecules and biologics for the treatment of chronic diseases is attracting industry players. These players have adopted strategies such as acquisitions, collaborations, and expansion of manufacturing units to strengthen their position in the market.

Key players operating in the Active Pharmaceutical Ingredients and High Potency API Industry are:

• Merck & Co., Inc.
• AbbVie, Inc.
• Bristol-Myers Squibb Company
• Boehringer Ingelheim International GmbH
• Cipla, Inc.

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