How Synthetic Cannabinoids Work
These chemicals act as full agonists at the CB1 and CB2 receptors in your brain and body. This technical detail is a major difference from natural THC. Natural THC acts only as a partial agonist. Because synthetic versions activate the receptors fully, they produce much more intense effects.
JWH-018 has a specific chemical center called an indole core. This structure differs completely from the shape of natural THC. This difference changes how the **** sticks to your receptors and how your body breaks it down. These changes lead to high levels of toxicity. Some versions, like HU-210, possess a strength at least 100 times greater than natural marijuana.